Personally I would hang on but it really depends on you... it was tough for me in my first trimester cuz i had bad nausea too but thankfully it got better in my second trimester.. There are many factors to consider if you were to resign now especially financially wise.. are you prepared to lose your income for the next many months until you give birth? in the interim when you feel better, it will be difficult to find a new perm job as most companies will not wanna hire pregnant ladies. also, you will need to give up on your maternity leave benefits too. If you really feel like you can't take it anymore, you can discuss with your husband and see if you can work things out if you were to resign. Alternatively, you may wanna talk to your boss again and explore other options or arrangements. not sure if that will change anything since you've alr spoken to him/her before. All the best!