I would suggest asking him how he intends to handle this. I would think that he will know how to handle it. But if he comes to you for advice, if I were you, I would simply advise him to treat all his friends the same. Personally, I think you don't have to worry too much as children this age still does not have the concept of romantic love. The teasing is probably harmless and would go away soon. I think it is a great opportunity for you to see how your boy handles such interactions. Will let you know more about his personality.
Encourage him to put friendship first -- be it with the boys or girls in his class. Don't discourage him to stay away from girls because this will not be good for his future social skills. Tell him that it's okay to have "girl friends" (not girlfriends) and encourage him to have as many friends as he wants. Hopefully he grows up to appreciate the value of friendship and use that as a foundation when he is ready to have actual BGR.