Hi! Honestly, I'm not familiar with Calmoseptine, is it for diaper rash or something else? Para sure, better to check the instructions on the packaging or ask your pedia kasi different products have different guidelines. A few of us mums usually apply rash creams either after every diaper change or as directed on the label, pero it really depends on the product. Let me know what it's for and I might be able to help more!