Ay, safe na yan after 21 days ng consistent intake, pero importante talaga na sigurado ka na hindi ka nag-miss ng pills kahit isang araw kasi that's when it becomes less effective! A few of my mum friends who are on Diane swear na they follow the 21-day rule strictly, at honestly yan ang standard guidance, pero para sa peace of mind mo talaga, better to check with your OB kasi alam nila exactly kung ano ang pinaka-safe timing para sa iyo based sa how regularly ka nag-take ng pills.