Super safe. Technically, pag buntis ka, nagpoproduce naman talaga katawan mo ng progesterone to support the growing baby. Kaya ka pinagte-take ng heragest para maboot yung progesterone mo to ensure the baby's safety kaya nga deemed siya as "pampakapit". I took heragest vaginally din for my whole first trimester, 3x a day pa nga. :)