If they already know how to spit, pwede mo na sila bigyan ng toothpaste with fluoeide like Colgate. Usually at the age of 2, marunong na sila mgspit and that's when the dentist starts recommending fluoride toothpaste pero dapat minimal amount pa rin ang ilalagay mo. You may check this out for more tips: http://www.colgate.com/en/us/oc/oral-health/life-stages/infant-oral-care/article/babys-first-teeth-should-you-use-toothpaste-1013